![]() ![]() In this study, afoxolaner was administered at fortnighly interval for one month then at a monthly interval for two additional months and demonstrated > 99% reduction in mite counts. canis has been demonstrated in one laboratory study involving naturally infested animals conducted in South Africa. Among the isoxazolines, the efficacy of afoxolaner against D. Recently, a new class of insecticides/acaricides, the isoxazolines, demonstrated very good efficacy against many ectoparasites of dogs and cats: fleas and ticks, but also mites, including Otodectes cynotis, Sarcoptes scabiei, Lynxacarus radovskyi and Demodex canis. Many treatment protocols in the field include off label use of macrocyclic lactone, providing variable efficacy with potential for toxicity, especially in dogs carrying MDR-1 gene mutations. Only a few drugs and formulations, either topical or systemic, are registered. Generalised demodicosis is a very challenging disease to treat effectively. ![]() Alternatively, skin biopsy or hair plucks may also be performed. Suspicion of demodicosis based on clinical signs has to be confirmed by the detection of mites in deep skin scrapings. Secondary severe bacterial infections are frequent. In the case of generalised demodicosis, the affected areas are frequently erythematous, with comedones, hair loss, follicular papules to pustules, and scales. Recently, it has been proposed that localised demodicosis is characterised as no more than four lesions with a diameter of up to 2.5 cm, while canine generalised demodicosis is characterised by five or more affected areas, or by lesions covering an entire region of the body, and/or demodectic podal dermatitis involving two or more paws. ![]() It may evolve from the localised condition or occur spontaneously especially in older animals with underlying diseases. Generalised demodicosis is more severe and can even be fatal if a secondary bacterial infection develops. It can regress spontaneously without treatment. The localised form appears as patches of alopecia and mild erythema in limited areas of the body, usually in young dogs, although it may also affect older ones. Canine demodicosis is classically divided into two main clinical manifestations, i.e. The evolution from asymptomatic carriage to skin disease may be related to a particular cellular immunodeficiency allowing the multiplication of the mites, although the pathogenesis is not yet elucidated. Puppies acquire mites from their mother in the first days of their life through direct skin contact. A small number of mites are usually considered as a normal component of the dog’s skin microbiota, but their proliferation leads to a potentially serious condition. It is a parasitic disease caused by mites of the genus Demodex. This clinical field study demonstrated that monthly administrations of afoxolaner in NexGard® or NexGard Spectra®, offered a convenient and reliable solution for the treatment of canine generalised demodicosis.ĭemodicosis is one of the most frequent skin conditions in dogs. In addition, the skin lesion severity and extent scores as well as the pruritus were all significantly lower at all post-treatment visits compared to the pre-treatment assessment. The number of mites was reduced by 87.6%, 96.5% and 98.1% on Days 28, 56 and 84, respectively. Treatments were well tolerated in all dogs and resulted in a rapid reduction of mites, with all post-treatment mite counts significantly lower than baseline. Efficacy of the treatments was assessed monthly by Demodex mite counts and physical examination with special regard to the severity and extension of skin lesions. Of the 50 dogs enrolled, 48 completed the whole study. Dogs were orally treated with afoxolaner three times at monthly intervals. MethodsĬlient-owned dogs, diagnosed positive for Demodex mites by pre-treatment skin scrapings and presenting clinical signs of generalised demodicosis were included. A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland. ![]()
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